A fatal crash involving a Christian motorcycle gang has closed all Melbourne-bound lanes of the Hume Freeway.

Four bikes collided in Wandong just after 1pm.

The Hume Freeway is closed citybound between Wandong and Wallan and is expected to remain closed for some time.

One rider, who is yet to be formally identified, has died.

Three others have been taken to hospital with non-life-threatening injuries.

Press PLAY below to hear from a witness

More to come…

(Image: Nine)