A man has been arrested following an alleged hit-run that killed a motorcyclist at Cranbourne North on Thursday.

Police have been told a motorcyclist and vehicle collided on Thompsons Road near the intersection of Lansell Drive about 1.40am.

The rider died at the scene.

It will be alleged the driver of the silver-coloured Holden Commodore briefly stopped before it continued driving west on Thompsons Road without assisting the rider.

A 30-year-old man was arrested at Frankston Train Station on Thursday afternoon and is assisting police with their investigation.

Anyone who witnessed the hit-run, who has dash cam footage, or thinks they may have seen the vehicle involved is urged to contact Crime Stoppers on 1800 333 000 or crimestoppersvic.com.au